An increase in inflammation in women with asthma, rheumatoid arthritis, psoriatic arthritis, and appendicitis has been noted during late phase of menstrual cycle. In this study of 76 regularly menstruating (28 day cycle) adult women (mean age 31.5) with uveitis, an increase in incidence of acute anterior uveitis was noted during late stage of menstrual cycle. Late stage of menstrual cycle was defined as postovulatory, starting on day 17 of menstrual cycle. Some attacks were also noted on day 9-12 and days 13-16, but the greatest number of attacks occurred on days 25-29. 17 % were on oral contraception, but contraception therapy has same decrease in hormones on day 22 of pill pack as during the late stage of menstrual cycle. The authors postulated that the rapid withdrawal of the anti-inflammatory effects of estrogen and/or progesterone in the late luteal phase may explain the increase in inflammatory attacks during late menstrual cycle.
